In 1981, the Pac-Man sequel was presented in the form of his girlfriend, Ms. Pac-Man. This sequel continues the original gameplay of the game "Eat Dots / Avoid Ghosts", but with new features to keep the title fresh.

Like her boyfriend, Pac-Man tries to navigate four different mazes filled with dots and bouncing fruits, each with their own unique personality and tactics, Inky, Blinky, Avoid Pinky, and Sue. A touch of any of these ghosts means Mispackman has lost his life.

Mrs. Pac-Man can reverse the flow of the tracker by eating one of the four energizers in the maze. During this time, the ghost will turn blue and Miss PacMan will be able to eat the ghost with bonus points (increased by 200, 400, 800, 1600). The power of the Energizer lasts for a limited time as the ghost's eyes return to the center box and reborn to hunt Miss Packman again.

After a few rounds of survival, players will be able to witness a humorous episode showing the growing romantic relationship between Pac-Man and Miss Pac-Man, leading to the advent of "Junior".